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Encoded Porous Beads for Label-Free Multiplex Detection of Tumor Markers

Update time: 7/8/2010 2:53:37 AM  Views: 29  【 Font: Large Medium Small 】【Print

Advanced Materials Volume 21 Issue 5, Pages 569 - 572

Yuanjin Zhao 1, Xiangwei Zhao 1, Jing Hu 1, Ming Xu 1, Wenju Zhao 1, Liguo Sun 1, Cun Zhu 1, Hua Xu 1, Zhongze Gu 1 2 *
1State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 (P.R. China)
2Laboratory of Environment and Biosafety Research Institute of Southeast University in Suzhou Suzhou 215123(P.R. China)
email: Zhongze Gu (gu@seu.edu.cn)

*Correspondence to Zhongze Gu, State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 (P.R. China).

Funded by:
 Ministry of Science and Technology; Grant Number: 2006AA03Z331
 National Science Foundation of China; Grant Number: 20573018, 60121101, 20703010
 Jiangsu Natural Science Foundation; Grant Number: BK2008318

Keywords
Opals • Inverse opaline photonic bead • Label-free assay • Suspension array • Tumor marker

Abstract
Inverse-opaline photonic beads are used as the elements of a suspension array for label-free multiplex immunoassays. As in the case of tumor-marker detection, specific binding of tumor markers on the pore surfaces of the beads results in a shift in the diffraction-peak position, which can be used for quantitatively estimating the amount of bound tumor marker.
             

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